Semantic satiation refers to the observation that repeated exposure to a meaningful item can temporarily reduce access to its meaning. While this effect has been studied mainly with spoken and written words, our short-term collaboration as part of MultiCom aims to adapt the semantic satiation paradigm to gesture comprehension by repeatedly presenting gesture videos and measuring subsequent semantic processing in a classical behavioural paradigm such as, for example a semantic categorization task. By comparing different gesture types, such as emblematic and iconic gestures, the study will provide a first test of whether meaning “fatigue” extends to visual-manual communication and to which kinds of visual expressions. In this presentation, we will provide an update on the status of as well as first preliminary results from our ongoing short-term collaboration.