Introduction. Congenital deafness and sign language acquisition provide a unique model for investigating how sensory and language-related experience shape structural brain organization. Neuroimaging studies have consistently demonstrated that sign languages recruit the same core left-lateralized fronto-temporal language network that supports spoken language processing, while additionally engaging dorsal sensorimotor pathways implicated in visuomotor integration, articulatory control, and language externalization. Structural neuroimaging studies comparing deaf signers and hearing non-signers have repeatedly reported alterations in several cortical regions, including Heschl’s gyrus and insula, while dorsal fronto-parietal regions have been implicated in modality-specific sensorimotor and externalization processes. However, structural findings across studies remain highly inconsistent, likely reflecting methodological heterogeneity, relatively small sample sizes, as well as differences in morphometric measures and analytical approaches. Methods and Expected Results. Here, we present a multimethod morphometric study investigating structural brain differences between 24 congenitally deaf signers and 24 hearing non-signers in an independent sample. Region-of-interest (ROI) analyses focus on bilateral insula and Heschl’s gyrus, as well as dorsal premotor cortex and inferior parietal cortex. The insula and Heschl’s gyrus were selected based on previous deafness-related morphometric findings, whereas inferior parietal and dorsal premotor regions were included based on contemporary neurobiological models implicating dorsal sensorimotor pathways in language externalization and visuomotor integration. The present study further addresses several limitations of the existing literature by integrating multiple complementary morphometric measures within a unified analytical framework and by combining hypothesis-driven ROI analyses with exploratory whole-brain approaches. In contrast to previous studies focusing on isolated morphometric indices or analytical techniques, the present study jointly examines cortical thickness, surface area, and cortical volume using surface-based and voxel-based approaches. ROI analyses provide increased sensitivity for theoretically motivated regions, whereas complementary whole-brain analyses allow the detection of distributed structural effects in grey and white matter beyond predefined ROIs. Cortical thickness, surface area, and cortical volume are assessed using FreeSurfer-based morphometry within the Desikan-Killiany atlas framework. Additional exploratory analyses include vertex-wise ROI visualizations, asymmetry index analyses, gray-to-white matter ratio analyses, and white matter control analyses. Sensitivity analyses restricted to native signers are conducted for the primary ROI analyses to assess the robustness of the findings. Discussion and Outlook. We investigate whether structural adaptations associated with deafness and sign language experience converge across complementary morphometric measures and analytical approaches. Given the heterogeneity of the existing literature, no strong directional hypotheses are formulated regarding the specific morphometric measures or direction of expected effects. By integrating ROI-based and whole-brain analyses, the present study aims to clarify inconsistencies in the literature and provide a more comprehensive characterization of structural neuroplasticity associated with deafness and early sign language acquisition.